You need melds worth at least 101 points to open in 101 Okey, which is where the game gets its name.

Each tile counts for its number value, and the okey and blanks take the value of the tile they represent. Your opening melds, valid runs and sets, must total 101 or more. Alternatively, you can open on five pairs instead of reaching the points threshold. Until you meet one of these conditions, your tiles stay on your rack and you cannot lay off any tiles.